We are looking to hire a postdoctoral scholar to study the role of microbial bile acid metabolism in host/microbiome crosstalk related to gut inflammation and GI health. This position is funded by an NIH R01 grant from the National Institute of Diabetes and Digestive and Kidney Diseases focused on identifying and characterizing microbial molecules. This project will focus on novel bile acids recently discovered called Microbially Conjugated Bile Acids (MCBAs). These diverse microbial molecules are produced by the human gut microbiome, but little is known about their effects on human health. Experiments will focus on understanding how MCBAs interact with human cells through cellular receptors with effects on epithelial barrier integrity and inflammatory signaling. The experiments will use both microbial and human cell culture and mouse models to identify MCBAs with the strongest bioactivity. This project provides unique opportunities to interact with other laboratories funded by the same NIH initiative to better understand how the human gut microbiome interacts with small molecules.
The work with involve culturing bacteria in an anaerobic environment to study their bile acid transformations and performing multi-omics analysis of microbial consortia. This includes mass spectrometry, microbiome sequencing and transcriptomics. Other duties will include maintenance and experimentation with knockout mouse models and analysis of data from cell culture experiments performed by collaborating labs and centers at Michigan State University.
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, citizenship, age, disability or protected veteran status.
Doctorate -Biochemistry, Microbiology, Physiology, related
PhD in biochemistry, microbiology, physiology or related field.
Experience with mass spectrometry data generation and analysis, mouse husbandry, molecular and microbiology biology techniques, and nucleic acid sequencing.
Curriculum vitae
cover letter
list of at least three references with their contact information
This is a 1-year assignment initially, with renewal based on sufficient project progress and available funding.
Michigan State University has been advancing the common good with uncommon will for more than 160 years. One of the top research universities in the world, MSU pushes the boundaries of discovery and forges enduring partnerships to solve the most pressing global challenges while providing life-changing opportunities to a diverse and inclusive academic community through more than 200 programs of study in 17 degree-granting colleges.
About Michigan State University
Spartans work every day to advance the common good in uncommon ways.Together, we tackle some of the world?s toughest problems to find solutions that make life better?from alternative energy to better food safety to breakthrough medical and environmental applications achieved through rare isotope research.We teach. We explore and we discover. We collaborate and lead. We innovate, inspire, and empower. We achieve our potential and create circumstances that help our students and others achieve theirs.We're good at it, and we've been at it for more than 150 years.The nation?s pioneer land-grant university, MSU began as a bold experiment that democratized higher education and helped bring science and innovation into everyday life. The revolutionary concept became a model for the nation.Today, MSU is one of the top research universities in the world?on one of the biggest, greenest campuses in the nation. Home to nationally ranked and recognized academic, residential college, and service-learning programs, we?re a diverse community of dedicated students and scholars, athletes and artists, scientists and leaders.In ways both practical and profound, we work to create a stronger, more sustainable, and more hopeful future for all.
Connections working at Michigan State University...indoor & outdoor lifting, handling and moving of heavy loads Essential Functions Riggers will be required to use typical rigging equipment that includes but is not limited to straps, cables, chains, slings, block and tackle, pulleys, and booms Riggers will...
DescriptionAs part of a clinical research team in the Department of Anesthesiology, the Staff Research Associate is primarily responsible for the conduct of clinical trials and research studies performed by the faculty including: subject recruitment and enrollment, study...
...difference in the life of a child. Job Description: The Speech Language Pathologist Assistant (SLPA) employed in a school setting works under... ...supervision of a certified Speech Language Pathologist (SLP) to provide therapeutic and educational services to students...
..., we are a leader in global commercial real estate due diligence, committed to delivering... ...prioritize excellence, service, employee development, and work-life balance. At Nova, you'll... .... During your 10-12 weeks with us, interns will be paired with a dedicated mentor...
HOME ORGANIZATION DESIGNER If you can answer "yes" to these questions, then you should become a Designer for Closet Factory Jacksonville.* Are you considered a "people person"?* Do you like being creative?* Can you appreciate good design and aesthetics?* Do you...